Anti-GPAA1 antibody produced in rabbit

产品说明

免疫原

Synthetic peptide directed towards the C terminal region of human GPAA1

应用

Anti-GPAA1 antibody produced in rabbit is suitable for western blotting at a concentration of 0.5μg/ml. It is also useful for immunohistochemistry at a concentration of 4-8μg/ml.

生化/生理作用

GPAA1 [glycosylphosphatidylinositol anchor attachment 1 homolog (yeast)] gene also referred to as GAA1 or hGAA1 encodes a protein which is a component of a transamidase. It is located at 8q24.3 and contains twelve exons that span about 4kb. It plays a pivotal role in GPI anchoring at the GPI transfer step where it catalyzes the attachment of GPI to proteins containing a C-terminal GPR attachment signal. GPAA1 gene amplification results in overexpression of RNA and protein in hepatocellular carcinoma (HCC). Hence, it facilitates as a potential amplification target and regulates the behavior of tumor cells.

序列

Synthetic peptide located within the following region: LGSLFLWRELQEAPLSLAEGWQLFLAALAQGVLEHHTYGALLFPLLSLGL

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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