Anti-GPR39 antibody produced in rabbit

产品说明

一般描述

GPR39 (G protein-coupled receptor 39) is an orphan member of the ghrelin receptor family expressed in brain and other peripheral tissues.
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4.

免疫原

Synthetic 20 amino acid peptide from C-terminus of human GPR39. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon (95%); Marmoset (85%).

应用

Anti-GPR39 antibody produced in rabbit is suitable for western blot at a concentration of 5μg/mL.

生化/生理作用

GPR39 (G protein-coupled receptor 39) exerts ligand-independent signaling activity. It is mainly involved in the regulation of growth hormone secretion. It facilitates the functional activities of the growth hormone-releasing peptides (GHRPs) and non-peptide ligands such as L-692,429 and MK-0677. It has been studied that zinc ion triggers GPR39 activity during food intake and energy metabolism. Study also shows that GPR39 may control the neuronal activity not only by altering transmitter expression and release but also through altering neuronal plasticity.

特点和优势

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外形

Supplied at 1 mg/ml
Solution in phosphate-buffered saline containing less than 0.1% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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