Anti-HCLS1 (AB2) antibody produced in rabbit

产品说明

一般描述

HCLS1 is a mitochondrial protein that is predominantly expressed in cardiac and skeletal tissues. This protein is known to interact with HAX1 and LEF-1 which, in turn, regulates granulocyte colony-stimulating factor (G-CSF)-mediated granulopoiesis.
Rabbit Anti-HCLS1 antibody recognizes human, rat, mouse, chicken, canine, bovine, and zebrafish HCLS1.

免疫原

Synthetic peptide directed towards the N terminal region of human HCLS1

应用

Rabbit Anti-HCLS1 (AB2) antibody can be used for western blot applications at a concentration of 1.25μg/ml.

生化/生理作用

HS1 which is hematopoietic lineage cell-specific protein 1, is a substrate of protein tyrosine kinases in lymphocytes, it binds to F-actin, and promotes Arp2/3 complex-mediated actin polymerization. However, the mechanism for the interaction between HS1 and F-actin has not yet been fully characterized. HS1 contains 3.5 tandem repeats, a coiled-coil region, and an SH3 domain at the C terminus. Unlike cortactin, which is closely related to HS1 and requires absolutely the repeat domain for F-actin binding, an HS1 mutant with deletion of the repeat domain maintains a significant F-actin binding activity. Deletion of the coiled-coil region abolished the ability of HS1 to bind to actin filaments and to activate the Arp2/3 complex for actin nucleation and actin branching.

序列

Synthetic peptide located within the following region: FGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGFGGKYGVERDRADKSAV

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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