Anti-Histone H2A (Acetyl-Lys⁵) antibody produced in rabbit

产品说明

一般描述

H2A histone family member Z (H2AFZ), which is a member of H2A family, is encoded by the gene mapped to human chromosome 4q24. H2AFZ is expressed highly at gene promoters, as well as other regulatory regions, generally involved in positive regulation of transcription. The encoded protein is characterized with N- terminal tail with five lysine residues involved In acetylation and it is associated with mitotic progression.

免疫原

The antiserum was produced against synthesized peptide derived from human Histone H2A around the acetylated site of Lys5.

Immunogen Range: 1-50

生化/生理作用

H2A histone family member Z (H2AFZ) is considered to be a pathogenic factor of schizophrenia in male patients. H2A.Z plays a vital role in various epigenetic events, such as transcription, chromosome segregation and heterochromatin organization. It also has an essential role in embryonic stem (ES) cell pluripotency and differentiation. Increased expression of H2A.Z leads to various type of cancers, including breast cancer, bladder cancer and malignant melanoma cells.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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