产品说明
一般描述
The MYST family of histone acetyltransferases, which includes MYST1, is named for the founding members MOZ (MYST3; MIM 601408), yeast YBF2 and SAS2, and TIP60 (HTATIP; MIM 601409). All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein-protein interactions and targeting transcriptional regulators to chromatin (Neal et al., 2000 [PubMed 10786633]).[supplied by OMIM].
MYST histone acetyltransferase 1 (MYST1), also known as human males absent on the first (HMOF), is encoded by the gene mapped to human chromosome 16p11.2. The encoded protein belongs to MYST family of histone acetyltransferases (HATs). MYST1 contains N-terminal chromodomain, involved in binding noncoding RNA and a central MYST histone acetyltransferase domain.
免疫原
HMOF/MYST1 (NP_115564, 414-449)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide at the C-term of human HMOF/MYST1.
生化/生理作用
MYST histone acetyltransferase 1 (MYST1) catalyzes the acetylation of Lys16 residue in histone H4. It also plays a vital role in various cellular processes, such as gene transcription, cell proliferation, differentiation and DNA repair response. MYST1 is essential for maintaining normal chromatin architecture of all cells of early male and female embryos.Aberrations in the gene expression leads to certain type of primary cancers.
外形
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | saturated ammonium sulfate (SAS) precipitated |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | immunohistochemistry: 1:50-1:100 indirect ELISA: 1:1000 western blot: 1:100-1:500 |
| NCBI登记号 | NP_115564 |
| UniProt登记号 | Q9H7Z6 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... MYST1(84148) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
