Anti-Interleukin-21 antibody produced in chicken

产品说明

一般描述

Interleukin-21 (IL-21) is a protein encoded by the IL21 gene in humans and is a proinflammatory cytokine complex. It is a CD132-dependent cytokine that plays a key role in regulating inflammation. IL21 is a central memory T cell-associated cytokine that promotes Th17 differentiation and IL-10 production. It also inhibits the generation of potentially pathogenic Th1/17 effector cells. IL21 plays a crutial role in T cell differentiation.

免疫原

Immunogen Sequence: GI # 11140821, sequence 18-146
Recombinant interleukin 21 [Mus musculus]

应用

Anti-Interleukin-21 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

生化/生理作用

Interleukin-21 plays an important role in the proliferation and maturation of natural killer (NK) cell populations from bone marrow, in the proliferation of mature B-cell populations co-stimulated with anti-CD40 and in the proliferation of T cells co-stimulated with anti-CD3. IL21 helps in B cell activation, expansion and PC (plasm cell) differentiation induced by direct interaction of B cells with activated T cells. It plays a critical role in antitumor immune responses. It is found to be associated with chronic inflammatory diseases including rheumatoid arthritis and inflammatory bowel disease. IL-21R is found in early human tendinopathy mainly expressed by tenocytes and macrophages. It may be closely related with the development and progression of coronary artery disease (CAD).

外形

Solution in phosphate buffered saline containing 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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