产品说明
一般描述
LCK (Lymphocyte-specific protein tyrosine kinase) gene belongs to Src family of protein tyrosine kinases (PTKs) and is localized to cytoplasm and cell membrane. It is mapped on to chromosome 1 at 1p34.3 and is organized in 13 exons, out of which, 12 are coding exons whereas one is putative 5′-noncoding exon.
免疫原
Synthetic peptide directed towards the N terminal region of human LCK
应用
Anti-LCK antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.
生化/生理作用
The protein encoded by the gene plays a pivotal role in the selection and maturation of developing T-cells. Lck binds to CD3ζ and inhibits CD59-triggered Ca 2+ signaling. It acts directly on TCR/CD3 pathway in Jurkat T cells and hence facilitates T cell responses.
序列
Synthetic peptide located within the following region: PSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLE
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 58 kDa |
| species reactivity | human, dog, rabbit, bovine, horse, mouse, guinea pig, rat |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI登记号 | NP_005347 |
| UniProt登记号 | P06239 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... LCK(3932) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
