产品说明
一般描述
MIER1 is a transcriptional regulator that may repress transcription by blocking the function of histone acetyltransferase.
Rabbit Anti-MIER1 antibody recognizes zebrafish, rabbit, bovine, chicken, canine, human, mouse, and rat MIER1.
免疫原
Synthetic peptide directed towards the middle region of human MIER1
应用
Rabbit Anti-MIER1 antibody can be used for western blot application at a concentration of 1.25 μg/ml.
生化/生理作用
The association of hMI-ER1 with Sp1 represents a novel mechanism for the negative regulation of Sp1 target promoters. Results demonstrate that alternate use of a facultative intron regulates the subcellular localization of hMI-ER1 proteins and this may have important implications for hMI-ER1 function in the regulation of transcription. Repressor activity is due to interaction and recruitment of a trichostatin A-sensitive histone deacetylase 1 (HDAC1).
序列
Synthetic peptide located within the following region: RRTGDEKGVEAIPEGSHIKDNEQALYELVKCNFDTEEALRRLRF
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 49 kDa |
| species reactivity | rabbit, dog, guinea pig, mouse, horse, bovine, human, rat |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI登记号 | NP_001071170 |
| UniProt登记号 | Q8NES5 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... MIER1(57708) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
