Anti-MTMR4 (C-term) antibody produced in rabbit

产品说明

一般描述

Myotubularin related protein 4 (MTMR), a member of the myotubularin family, alternatively known as FYVE (Fab1p, YO1B, Vac1p and EEA1) domain-containing dual specificity protein phosphatase 2 (FYVE-DSP2), encodes an intracellular protein of 1,195 amino acids, and shares approximately 47% sequence identity with MTMR3, spiking to over 70% identity in the catalytic domain and the double zinc finger (FYVE) motif. MTMR4 resides predominantly in the endosomal structures. PCR analysis detects expression of MTMR4 in all human tissues examined except lung, small intestine, stomach, salivary gland, adrenal gland, and uterus. Subcellular localization of MTMR4 in transfected HeLa cells showed a perinuclear distribution, similar to that seen with MTMR3. In human chromosome, the gene MTMR4 is localized on 17q22-q23.

免疫原

MTMR4 (NM_004687, 1159-1197)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human MTMR4.

生化/生理作用

Myotubularin related protein 4 (MTMR4) dephosphorylates para-nitrophenylphosphate and phosphatidylinositol 3-phosphate. MTMR4 plays a major role in vesicular trafficking and signal transduction. MTMR4 also dephosphorylates receptor-regulated small mothers against decapentaplegic homolog (R-Smads) and maintains transforming growth factor-beta (TGF-β) levels and thereby regulates its signalling pathway. MTMR4 interaction with Nedd4 (neural-precursor-cell- expressed developmentally down-regulated 4) leads to progression of skeletal muscle atrophy.

外形

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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