Anti-NCOR2 (AB2) antibody produced in rabbit

产品说明

一般描述

NCOR2 is a nuclear receptor corepressor that facilitates transcriptional silencing. This repressor has been studied as a biomarker to predict treatment efficacy in estrogen receptor-positive breast cancer patients. NCOR2 is also known to function as a prognostic indicator for breast cancer.
Rabbit anti-NCOR2 antibody recognizes pig, human, mouse, and rat NCOR2.

免疫原

Synthetic peptide directed towards the N terminal region of human NCOR2

应用

Rabbit anti-NCOR2 antibodies have been used for immunohistochemistry at 1:50 dilution. The antibody can also be used for western blotting at 2.5μg/ml.

生化/生理作用

NCOR2 forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. NCOR2 mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.

序列

Synthetic peptide located within the following region: DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEA

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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