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Anti-NCOR2 (AB2) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
AV32464
规格纯度
IgG fraction of antiserum
参考价格
3311.54 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-NCOR2 (AB2) antibody produced in rabbit
Anti-Nuclear receptor co-repressor 2
产品介绍:

产品说明

一般描述

NCOR2 is a nuclear receptor corepressor that facilitates transcriptional silencing. This repressor has been studied as a biomarker to predict treatment efficacy in estrogen receptor-positive breast cancer patients. NCOR2 is also known to function as a prognostic indicator for breast cancer.
Rabbit anti-NCOR2 antibody recognizes pig, human, mouse, and rat NCOR2.

免疫原

Synthetic peptide directed towards the N terminal region of human NCOR2

应用

Rabbit anti-NCOR2 antibodies have been used for immunohistochemistry at 1:50 dilution. The antibody can also be used for western blotting at 2.5μg/ml.

生化/生理作用

NCOR2 forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. NCOR2 mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.

序列

Synthetic peptide located within the following region: DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEA

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 275 kDa
species reactivityhuman
浓度0.5 mg - 1 mg/mL
technique(s)western blot: suitable
NCBI登记号NP_001070729
UniProt登记号Q9Y618
运输wet ice
储存温度−20℃
Gene Informationhuman ... NCOR2(9612)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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