产品说明
一般描述
Programmed cell death protein 1 (PDCD1) is part of the cluster of differentiation 28 (CD28) superfamily. It interacts with its ligands, that is, programmed death ligand-1 and -2 (PD-L1/PD-L2). The gene encoding this protein is localized to human chromosome 2q37.
免疫原
Synthetic peptide from human PDCD1 / CD279.
生化/生理作用
Programmed cell death protein 1 (PDCD1) plays an important role in the immune regulation by acting as a negative co-stimulatory factor. It suppresses the functions and multiplication of T cells, thereby reducing the release of IL-2 (interleukin-2), IL-10 and IFN-γ (interferon γ). In the presence of tumor microenvironment, PDCD1 along with its ligand modulates T effector functioning, thereby protecting cancer cells from immune-associated rejection. Mutation in this gene is associated with symptoms and progression of multiple sclerosis and susceptibility to systemic lupus erythematosus.
特点和优势
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外形
Solution in phosphate-buffered saline containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | mouse, human, rat |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable western blot: suitable |
| UniProt登记号 | Q15116 |
| 储存温度 | −20℃ |
| Gene Information | human ... PDCD1(5133) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
