产品说明
一般描述
PHB2 codes for prohibitin 2 that protects the cohesion of sister chromatids during mitosis. PHB2 downregulation has been linked to anorexia-induced fission and apoptosis in mitochondria.
Rabbit Anti-PHB2 antibody recognizes bovine, chicken, human, mouse, rat, and canine PHB2.
免疫原
Synthetic peptide directed towards the N terminal region of human PHB2
应用
Rabbit Anti-PHB2 (AB2) antibody is suitable for western blot applications at a concentration of 1μg/ml.
生化/生理作用
PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). It functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. PHB2 competes with NCOA1 for modulation of ER transcriptional activity. It probably involved in regulating mitochondrial respiration activity and in aging.
序列
Synthetic peptide located within the following region: WFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQR
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 33 kDa |
| species reactivity | horse, mouse, rabbit, rat, bovine, human, dog, guinea pig |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI登记号 | NP_001138303 |
| UniProt登记号 | Q99623 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PHB2(11331) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
