产品说明
一般描述
The gene CD19 (B-lymphocyte antigen) is located on human chromosome 16p11. The encoded protein is a transmembrane protein which is specific to B-cells.
免疫原
The antiserum was produced against synthesized peptide derived from human CD19 around the phosphorylation site of Tyr531.
Immunogen Range: 501-550
生化/生理作用
CD19 (B-lymphocyte antigen) plays an important role in BCR (B cell receptor) signaling. It serves as a B cell receptor (BCR) co-receptor. In B cells, phosphorylated CD19 induces signaling of SRC-family kinase (SFK) LYN and tyrosine kinases. It also participates in B-cell selection and differentiation. In mice, overexpression of CD19 causes hyper-responsive to BCR induction, thus resulting in lupus-like autoimmune disease. Mutations in this gene can result in common variable immunodeficiency (CVID) in humans.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 61 kDa |
| species reactivity | human, mouse, rat |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:1000 western blot: 1:500-1:1000 |
| NCBI登记号 | P15391 |
| UniProt登记号 | P15391 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CD19(930) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
