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位置:首页 > 品牌 > Sigma-Aldrich > 抗-磷酸化-MAPK8/MAPK9/MAPK10 (pThr183/pTyr185) 兔抗

Anti-phospho-MAPK8/MAPK9/MAPK10 (pThr183/pTyr185) antibody produced in rabbit

抗-磷酸化-MAPK8/MAPK9/MAPK10 (pThr183/pTyr185) 兔抗

品牌
Sigma-Aldrich
货号
SAB4300261
规格纯度
affinity isolated antibody
参考价格
4618.16 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-phospho-MAPK8/MAPK9/MAPK10 (pThr183/pTyr185) antibody produced in rabbit
Anti-JNK-55 antibody produced in rabbit
Anti-FLJ12099 antibody produced in rabbit
Anti-JNK antibody produced in rabbit
Anti-mitogen-activated protein kinase 8 antibody produced in rabbit
抗-磷酸化-MAPK8/MAPK9/MAPK10 (pThr183/pTyr185) 兔抗
产品介绍:

产品说明

免疫原

Peptide sequence around phosphorylation site of Thr183/Tyr185 (M-M-T(p)-P-Y(p) - V - V ), according to the protein MAPK8/MAPK9/MAPK10.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4). /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it. /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 ~46 kDa
~54 kDa
species reactivitymouse, rat, human
浓度1 mg/mL
technique(s)indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
同位素/亚型IgG
免疫原序列(M-M-TP-P-YP-V-V)
NCBI登记号NP_001128516.1
NP_002741.1
NP_002744.1
UniProt登记号P45983
运输wet ice
储存温度−20℃
Gene Informationhuman ... MAPK10(5602), MAPK8(5599), MAPK9(5601)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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