产品说明
一般描述
Anti-PKC ζ antibody detects endogenous levels of total PKC ζ protein.
The PKC ζ (protein kinase C ζ) gene is mapped to human chromosome 1p36.33.
免疫原
The antiserum was produced against synthesized peptide derived from human PKC zeta.
Immunogen Range: 376-425
生化/生理作用
The PKC ζ (protein kinase C ζ) is a Zn2+-dependent kinase that is known to activate G protein-coupled receptor (GPR)39, contributing to the improvement of intestinal barrier function against S. typhimurium infection. PKC ζ acts as a tumor suppressor gene by inhibiting the invasion, cell growth and metastasis of cancer, such as prostate cancer. PKC ζ might serve as a biomarker for inflammatory diseases, as the gene is associated with the regulation of the nuclear factor κ-light-chain-enhancer of activated B cells (NF-ζB). Upregulation of the gene is observed in many of the human cancers, such as glioblastoma.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD00162775 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 67 kDa |
| species reactivity | rat, human, mouse |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:20000 immunofluorescence: 1:100-1:500 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI登记号 | Q05513 |
| UniProt登记号 | Q05513 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PRKCZ(5590) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
