Anti-POLR3B antibody produced in rabbit

产品说明

一般描述

POLR3B codes for polymerase (RNA) III (DNA directed) polypeptide B which forms a large subunit of RNA polymerase III. It is involved in the synthesis of ribosomal and transfer RNAs. Mutations in POLR3B have been linked to hypomyelinating leukoencephalopathy and leukodystrophy.
Rabbit Anti-POLR3B antibody recognizes chicken, canine, human, mouse, and rat POLR3B.

免疫原

Synthetic peptide directed towards the C terminal region of human POLR3B

应用

Rabbit Anti-POLR3B antibody is suitable for western blot applications at a concentration 1μg/ml.

生化/生理作用

POLR3B belongs to the RNA polymerase beta chain family. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3B is the second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It is proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

序列

Synthetic peptide located within the following region: IEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQED

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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