Anti-POU1F1 (AB1) antibody produced in rabbit

产品说明

一般描述

POU1F1 belongs to the POU domain-containing family of transcription factors that regulate cell-fate decisions. POU1F1 mutations have been linked to pituitary hormone deficiency.
Rabbit Anti-POU1F1 (AB1) antibody recognizes bovine, pig, chicken, canine, human, mouse, and rat POU1F1.

免疫原

Synthetic peptide directed towards the N terminal region of human POU1F1

应用

Rabbit Anti-POU1F1 (AB1) antibody can be used for western blot applications at 1μg/ml.

生化/生理作用

PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 of mammals, and Unc-86 of C. elegans. PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone and prolactin. PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit by thyrotropin-releasing hormone and cyclic AMP.

序列

Synthetic peptide located within the following region: TPCLYKFPDHTLSHGFPPIHQPLLAEDPTAADFKQELRRKSKLVEEPIDM

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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