Anti-PPAPDC1B antibody produced in rabbit

产品说明

一般描述

The gene phosphatidic acid phosphatase type 2 domain containing 1B (PPAPDC1B; HTPAP) is mapped to human chromosome 8p12. It is widely expressed in human tissues.

免疫原

Synthetic peptide directed towards the middle region of human PPAPDC1B

应用

Anti-PPAPDC1B antibody produced in rabbit is suitable for western blotting at a concentration of 0.5μg/ml.

生化/生理作用

Phosphatidic acid phosphatase type 2 domain containing 1B (PPAPDC1B; HTPAP) is a transmembrane protein phosphatase that blocks anchorage-dependent growth of fibroblasts by interfereing with multiple signaling pathways. It is a potential therapeutic target in breast cancer as it stimulates estrogen receptor pathway. HTPAP also suppresses metastasis in human hepatocellular carcinoma. PPAPDC1B also regulates survival of small-cell lung cancer and pancreatic cancer cell lines.

序列

Synthetic peptide located within the following region: KLIVGRPRPDFFYRCFPDGLAHSDLMCTGDKDVVNEGRKSFPSGHSSFAF

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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