Anti-PTK2B (AB2) antibody produced in rabbit

产品说明

一般描述

PTK2B is a tyrosine kinase that is involved in MAP kinase signaling pathways. Studies in mice have shown that PTK2B exhibits sexually dimorphic expression patterns during gonadal development.
Rabbit Anti-PTK2B (AB2) antibody recognizes bovine, canine, human, mouse, and rat PTK2B.

免疫原

Synthetic peptide directed towards the C terminal region of human PTK2B

应用

Rabbit Anti-PTK2B (AB2) antibody can be used for western blot applications at a concentration of 1.25μg/ml.

生化/生理作用

PTK2B encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies.

序列

Synthetic peptide located within the following region: QKQMVEDYQWLRQEEKSLDPMVYMNDKSPLTPEKEVGYLEFTGPPQKPPR

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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