产品说明
一般描述
Bcl-2 inhibitor of transcription/peptidyl-tRNA hydrolase 2 (PTRH2, BIT1, PTH2) is a mitochondrial protein released into the cytoplasm during apoptosis. Bit1 complexes with AES, a small Groucho/transducin-like enhancer of split (TLE) protein, to induce caspase-independent apoptosis. Bit-1 is a mediator of anoikis in cells that lose integrin-mediated cell attachment.
特异性
Anti-PTRH2 polyclonal antibody reacts with bovine, human, mouse, rat, canine, chicken, and zebrafish Bcl-2 inhibitor of transcription proteins.
免疫原
Synthetic peptide directed towards the C terminal region of human PTRH2
应用
Anti-PTRH2 polyclonal antibody is used to tag Bcl-2 inhibitor of transcription for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles Bcl-2 inhibitor of transcription in non-caspase apoptosis and cell anoikis.
生化/生理作用
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
序列
Synthetic peptide located within the following region: RNPEMLKQWEYCGQPKVVVKAPDEETLIALLAHAKMLGLTVSLIQDAGRT
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 20 kDa |
| species reactivity | guinea pig, dog, human, horse, bovine |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI登记号 | NP_057161 |
| UniProt登记号 | Q9Y3E5 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PTRH2(51651) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
