您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > Anti-RFX4 (AB1) antibody produced in rabbit

Anti-RFX4 (AB1) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
AV39699
规格纯度
affinity isolated antibody
参考价格
6305.78 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-RFX4 (AB1) antibody produced in rabbit
Anti-regulatory factor X, 4 (influences HLA class II expression)
Anti-NYD-SP10
产品介绍:

产品说明

一般描述

RFX family of DNA binding proteins are transcriptional activators that recognize X-boxes (DNA of the sequence 5′-GTNRCC(0-3N)RGγAAC-3′, where N is any nucleotide, R is a purine and γ is a pyrimidine). Regulatory factor X, 4 (influences HLA class II expression) (RFX4, NγD-SP10) is a testis-specific dimeric DNA-binding protein that appears to regulate transcription via selective interactions with DNA and other RFX members. RFX4 appears to have a regulatory role in the transcription of testes histone (H1t), which is only expressed in pachytene spermatocytes, gene during spermatogenesis.

特异性

Anti-RFX4 (AB1) polyclonal antibody reacts with zebrafish, canine, human, mouse, and rat regulatory factor X, 4 proteins.

免疫原

Synthetic peptide directed towards the N terminal region of human RFX4

应用

Anti-RFX4 (AB1) polyclonal antibody is used to tag regulatory factor X, 4 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles regulatory factor X, 4 in testis development and spermatogenesis.

生化/生理作用

RFX4 is a transcription factors that contain a highly-conserved winged helix DNA binding domain. RFX4 is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. RFX4 may be a transcriptional repressor rather than a transcriptional activator.This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. This protein may be a transcriptional repressor rather than a transcriptional activator. Three transcript variants encoding different isoforms have been described for this gene.This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. This protein may be a transcriptional repressor rather than a transcriptional activator. Three transcript variants encoding different isoforms have been described for this gene.

序列

Synthetic peptide located within the following region: QQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGAAWVSETGK

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 64 kDa
species reactivitymouse, rat, rabbit, horse, dog, bovine, human, guinea pig
浓度0.5 mg - 1 mg/mL
technique(s)western blot: suitable
NCBI登记号NP_002911
UniProt登记号Q33E94
运输wet ice
储存温度−20℃
Gene Informationhuman ... RFX4(5992)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品