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Anti-RGS2 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
AV42827
规格纯度
IgG fraction of antiserum
参考价格
3311.54 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-RGS2 antibody produced in rabbit
Anti-Regulator of G-protein signaling 2
Anti-AL592303.1
Anti-GOS8
产品介绍:

产品说明

一般描述

Regulator of G-protein signaling 2 (RGS2, GOS8) is a negative regulator of G-protein coupled receptor (GPCR) signaling. RGS2 has been reported to regulate G(i/o)- and G(q)- and Gα/11 coupled receptors. RGS2 regulates signaling pathways gated by GPCRs such at the AT1 receptor and the melatonin MT(2) receptor. RGS2 regulates the PKC-η/PLD2 pathway and represses STAT3′s transcriptional activation of Nox1.

特异性

Anti-RGS2 polyclonal antibody reacts with human, bovine, pig, chicken, rat, mouse, and canine regulator of G-protein signaling 2 proteins.

免疫原

Synthetic peptide directed towards the middle region of mouse Rgs2

应用

Anti-RGS2 polyclonal antibody is used to tag regulator of G-protein signaling 2 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles regulator of G-protein signaling 2 in the regulation of G(i/o)- and G(q)- and Gα/11 coupled GPCR receptors.

生化/生理作用

Rgs2 inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. It may play a role in leukemogenesis.

序列

Synthetic peptide located within the following region: LKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINI

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 23 kDa
species reactivitydog, bovine, guinea pig, human, rat, horse, rabbit, sheep, mouse
浓度0.5 mg - 1 mg/mL
technique(s)western blot: suitable
NCBI登记号NP_033087
UniProt登记号O08849
运输wet ice
储存温度−20℃
Gene Informationmouse ... Rgs2(19735)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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