Anti-RRM1 (AB1) antibody produced in rabbit

产品说明

一般描述

Ribonucleotide reductase M1 polypeptide is the large subunit of ribonucleoside-diphosphate reductase which catalyzes the formation of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. Ribonucleotide reductase M1 (RRM1) is a molecular determinant that predicts cancer sensitivity or resistance to drugs like gemcitabine.

特异性

Anti-RRM1 (AB1) polyclonal antibody reacts with human, mouse, rat, bovine, canine, chicken, and zebrafish ribonucleotide reductase M1 polypeptides.

免疫原

Synthetic peptide directed towards the C terminal region of human RRM1

应用

Anti-RRM1 (AB1) polyclonal antibody is used to tag ribonucleotide reductase M1 polypeptide for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of ribonucleotide reductase M1 polypeptide in the formation of deoxyribonucleotides and as a predictor of chemotherapeutic effect of gemcitabine-related drugs.

生化/生理作用

RRM1 is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. Its gene is located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. Its gene may play a role in malignancies and disease that involve this region.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3′ end of STIM1 situated 1.6 kb from the 5′ end of this gene.

序列

Synthetic peptide located within the following region: MHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKER

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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