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Anti-RRM1 (AB2) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
AV46030
规格纯度
IgG fraction of antiserum
参考价格
3311.54 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-RRM1 (AB2) antibody produced in rabbit
Anti-ribonucleotide reductase M1 polypeptide
Anti-R1
Anti-RIR1
Anti-RR1
产品介绍:

产品说明

免疫原

Synthetic peptide directed towards the N terminal region of human RRM1

应用

Anti-RRM1 (AB2) antibody produced in rabbit is suitable for western blotting at a concentration of 1.25μg/ml.

生化/生理作用

Ribonucleotide reductase M1 (RRM1) gene encodes an enzyme Ribonucleoside-diphosphate reductase, large subunit, which is the regulatory subunit of ribonucleotide reductase. It is an essential precursor for DNA synthesis that catalyzes the synthesis of deoxyribonucleotides from the corresponding ribonucleotides. Increased expression of RRM1 protein in genetically modified lung-cancer cells enhances the expression of phosphatase and PTEN (tensin homologue), which is an inhibitor of cell proliferation. Further, it decreases the phosphorylation of focal adhesion kinase as well as reduces cell migration and invasiveness.

序列

Synthetic peptide located within the following region: ATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHL

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 90 kDa
species reactivityhuman, yeast, bovine, rabbit, rat, dog, guinea pig, horse, mouse
浓度0.5 mg - 1 mg/mL
technique(s)western blot: suitable
NCBI登记号NP_001024
UniProt登记号P23921
运输wet ice
储存温度−20℃
Gene Informationhuman ... RRM1(6240)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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