Anti-RRM1 (AB2) antibody produced in rabbit

产品说明

免疫原

Synthetic peptide directed towards the N terminal region of human RRM1

应用

Anti-RRM1 (AB2) antibody produced in rabbit is suitable for western blotting at a concentration of 1.25μg/ml.

生化/生理作用

Ribonucleotide reductase M1 (RRM1) gene encodes an enzyme Ribonucleoside-diphosphate reductase, large subunit, which is the regulatory subunit of ribonucleotide reductase. It is an essential precursor for DNA synthesis that catalyzes the synthesis of deoxyribonucleotides from the corresponding ribonucleotides. Increased expression of RRM1 protein in genetically modified lung-cancer cells enhances the expression of phosphatase and PTEN (tensin homologue), which is an inhibitor of cell proliferation. Further, it decreases the phosphorylation of focal adhesion kinase as well as reduces cell migration and invasiveness.

序列

Synthetic peptide located within the following region: ATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHL

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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