Anti-RUVBL2 (AB2) antibody produced in rabbit

产品说明

一般描述

RUVBL2 is an AS160-binding protein and is expressed in the cytosol. This cytosolic protein is involved in insulin-stimulated GLUT4 translocation. RUVBL2 is also involved in modulating the function of PIKK proteins. Furthermore, it is known to form macromolecular complexes that regulate the nonsense-mediated decay of premature mRNA transcripts.
Rabbit Anti-RUVBL2 (AB2) antibody recognizes bovine, canine, human, mouse, rat, and zebrafish RUVBL2.

免疫原

Synthetic peptide directed towards the N terminal region of human RUVBL2

应用

Rabbit Anti-RUVBL2 (AB2) antibody can be used for western blot (2-4μg/ml) and IHC (4-8μg/ml) applications.

生化/生理作用

RuvB-Like 2 (48-kDa TATA box-binding protein-interacting protein, Reptin 52, RUVBL2) is the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this protein has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.

序列

Synthetic peptide located within the following region: IERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVLEMIREGKI

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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