产品说明
一般描述
The gene SHISA6 (shisa family member 6) encodes a single transmembrane protein that is mainly expressed at hippocampal synapses. It is a member of the Shisa family of proteins and contains the characteristic cysteine-rich motif, a single-pass transmembrane region and a type-II PDZ (PSD95-Dlg1-zo-1)-ligand motif at the C-terminal tail of the intracellular domain.
生化/生理作用
The gene SHISA6 (shisa family member 6) encodes a directly interacting AMPAR (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor) auxiliary subunit. Its PDZ (PSD95-Dlg1-zo-1)-ligand motif is found to associate with PSD-95 ((postsynaptic density protein 95), and constrains the mobility of AMPARs in the plasma membrane. This restrains the AMPARs to postsynaptic densities and inhibits their desensitization during synaptic activity.
外形
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 55764 Da |
| species reactivity | human |
| technique(s) | immunohistochemistry: 1:50-1:100 western blot: 1:250-1:500 |
| NCBI登记号 | NP_997269.2 |
| UniProt登记号 | Q6ZSJ9 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
