Anti-SLC45A2 antibody produced in rabbit

产品说明

一般描述

Solute carrier family 45, member 2/melanoma antigen AIM1/membrane-associated transporter protein (SLC45A2, 1A1, AIM1, MATP) is a skin pigmentation protein involved in melanin biosynthesis. SLC45A2 is a melanoma-associated protein. Defective MATP is a cause of the hypopigmention condition oculocutaneous albinism type 4 (OCA4).

特异性

Anti-SLC45A2 polyclonal antibody reacts with human, mouse, rat, pig, bovine, and canine solute carrier family 45, member 2 proteins.

免疫原

Synthetic peptide directed towards the C terminal region of human SLC45A2

应用

Anti-SLC45A2 polyclonal antibody is used to tag solute carrier family 45, member 2 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of solute carrier family 45, member 2 in melanin biosynthesis, pigmentation and melanoma development.

生化/生理作用

SLC45A2 is a melanocyte differentiation antigen that is expressed in a high percentage of melanoma cell lines. A similar sequence gene in medaka, ′B,′ encodes a transporter that mediates melanin synthesis. Mutations in this gene are a cause of oculocutaneous albinism type 4.The protein encoded by this gene encodes a melanocyte differentiation antigen that is expressed in a high percentage of melanoma cell lines. A similar sequence gene in medaka, ′B,′ encodes a transporter that mediates melanin synthesis. Mutations in this gene are a cause of oculocutaneous albinism type 4. Alternative splicing results in multiple transcript variants encoding different isoforms.

序列

Synthetic peptide located within the following region: IGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNSTEFLIYERGVEVGCWGFC

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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