产品说明
一般描述
SMARCB1 is a tumor suppressor gene that is inactivated in epithelial cancers. Furthermore, studies have reported that SMARCB1 expression is absent in malignant rhabdoid cancers of kidney, CNS and soft tissues.
Rabbit Anti-SMARCB1 antibody recognizes bovine, chicken, canine, human, mouse, rat, and zebrafish SMARCB1.
免疫原
Synthetic peptide directed towards the middle region of human SMARCB1
应用
Rabbit Anti-SMARCB1 can be used for western blot applications at a concentration of 0.5 μg/ml.
生化/生理作用
The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Alternatively spliced transcript variants have been found for this gene.
序列
Synthetic peptide located within the following region: ILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSDQRVIIKLNIHV
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 43 kDa |
| species reactivity | bovine, dog, rabbit, rat, mouse, human, guinea pig |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI登记号 | NP_003064 |
| UniProt登记号 | Q12824-2 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... SMARCB1(6598) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
