您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > Anti-STAT6 (AB1) antibody produced in rabbit

Anti-STAT6 (AB1) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
AV31048
规格纯度
affinity isolated antibody
参考价格
6305.78 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-STAT6 (AB1) antibody produced in rabbit
Anti-D12S1644
Anti-STAT6B
Anti-IL-4-STAT
Anti-STAT6C
Anti-Signal transducer and activator of transcription 6, interleukin-4 induced
产品介绍:

产品说明

一般描述

Signal transducer and activator of transcription 6, interleukin-4 induced (STAT6) is a mediatior of interleukin-4 (IL-4) and IL-13 biological processes such as humoral immunity and clearance of helminthic parasites as well as the pathogenesis of allergic disorders like asthma, food allergies, and atopic dermatitis.
Rabbit polyclonal anti-STAT6 antibody reacts with canine, human, mouse, rat, and pig signal transducer and activator of transcription 6 proteins.

免疫原

Synthetic peptide directed towards the C terminal region of human STAT6

应用

Rabbit Anti-STAT6 (AB1) antibody can be used for western blot (1μg/ml) applications.
Rabbit polyclonal anti-STAT6 antibody is used to tag signal transducer and activator of transcription 6 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of Signal transducer and activator of transcription 6 in humoral immunity and allergic disorders.

生化/生理作用

Full-length human STAR6 (NP_003144) was expressed in E.coli as inclusion body and purified after protein refolding for mouse immunization. Clone 5B1 shows excellent western blot detection of endogenous STAT6 using ACHN cell lysate.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

序列

Synthetic peptide located within the following region: NLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPELQM

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 94 kDa
species reactivityguinea pig, dog, rabbit, horse, rat, bovine, mouse, human
浓度0.5 mg - 1 mg/mL
technique(s)immunohistochemistry: suitable
western blot: suitable
NCBI登记号NP_003144
UniProt登记号P42226
运输wet ice
储存温度−20℃
Gene Informationhuman ... STAT6(6778)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品