Anti-Tiparp (N-term) antibody produced in rabbit

产品说明

一般描述

The gene TIPARP (TCDD-inducible poly [ADP-ribose] polymerase) is mapped to human chromosome 3q25. It belongs to the poly [ADP-ribose] polymerase (PARP) family. The protein has a PARP catalytic domain, a WWE (tryptophan-tryptophan-glutamate) protein interaction domain and a CCCH-type zinc-finger domain. It is expressed in variety of tissues, including liver, heart, spleen, brain and reproductive organs.

免疫原

TIPARP (NP_849223, 65-100)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of mouse TIPARP.

生化/生理作用

TIPARP (TCDD-inducible poly [ADP-ribose] polymerase) is controlled by the aryl hydrocarbon receptor (AHR). It is a mono-ADP-ribosyltransferase and works as a transcriptional repressor of AHR. It is required for the transfer of ADP-ribose onto target proteins using NAD⁺. The environmental toxin 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin, dioxin (TCDD) increases the expression of this gene. It participates in the inhibition of hepatic gluconeogenesis mediated by TCDD.

外形

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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