产品说明
一般描述
Tumor necrosis factor (ligand) superfamily, member 12/ TNF-like weak inducer of apoptosis (TNFSF12, APO3L, DR3LG, TWEAK), a tumor necrosis factor (TNF) ligand family cytokine, is a pleiotropic cytokine that mediates its cell signaling effect via binding to the FN14/TWEAK receptor (TWEAKR). TNFSF12/TWEAK, which is expressed in many tissue types, is an inflammatory cytokine that induces chemokines and other proinflammatory cytokines. TNFSF12/TWEAK regulates progenitor cell proliferation, differentiation, and survival in multiple organ systems.
Rabbit polyclonal anti-TNFSF12 antibody reacts with human, mouse, and canine tumor necrosis factor (ligand) superfamily, member 12/TNF-like weak inducer of apoptosis cytokines.
免疫原
Synthetic peptide directed towards the N terminal region of human TNFSF12
应用
Rabbit polyclonal anti-TNFSF12 antibody is used to tag tumor necrosis factor (ligand) superfamily, member 12/TNF-like weak inducer of apoptosis for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of tumor necrosis factor (ligand) superfamily, member 12/TNF-like weak inducer of apoptosis in the regulation of progenitor cell proliferation, differentiation, and survival through FN14/TWEAK receptor cell signaling pathways. Anti-TNFSF12 antibody produced in rabbit is suitable for western blotting at a concentration of 1 μg/ml.
序列
Synthetic peptide located within the following region: QEELVAEEDQDPSELNPQTEESQDPAPFLNRLVRPRRSAPKGRKTRARRA
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 27 kDa |
| species reactivity | human |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI登记号 | NP_742086 |
| UniProt登记号 | O43508 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... TNFSF12(8742) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
