Anti-TXN antibody produced in rabbit

产品说明

一般描述

Thioredoxin (TXN) is a 12 kDa oxidoreductase enzyme containing a dithiol-disulfide active site, which is required for the redox regulatory function. It is widely expressed in many organisms from plants and bacteria to mammals. Multiple in vitro substrates for thioredoxin have been recognized, including ribonuclease, choriogonadotropin, coagulation factors, glucocorticoid receptor and insulin. Reduction of insulin is classically used as an activity test. TXN is encoded by the gene mapped to human chromosome 9q31.

免疫原

TXN (NP_003320.2, 1 a.a. ~ 105 a.a) full-length human protein.

Sequence
MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV

生化/生理作用

Thioredoxin (TXN) plays an important role in protecting cells against apoptosis under oxidative stress by enhancing the total antioxidant ability, reducing the reactive oxygen species (ROS) levels as well as by stabilizing the actin cytoskeletal system. It also plays an essential role in donating deoxyribonucleotides for DNA replication.

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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