纯度规格:A cell-permeable compound that directly and reversibly interacts with miRNA binding domain of Argonaute-2 (Kd = 126 μM) and inhibits binding of miR-20a, miR-26a, miR-107, miR-223 &let-7a to Ago2.
纯度规格:Enhances BMP-2 associated signaling by inhibiting Smurf1-mediated Smad1/5 ubiquitination and thereby prolonging the half-life of Smad1 and 5. in 48 h).
纯度规格:A cell-permeable structural analog of E1 that acts as an equipotent, SAM-competitive inhibitor of Ezh2/PRC2 inhibitor (Ki = 0.5 to 3 nM against wt &mutant Ezh2-containing PRC2).
纯度规格:Cell-permeable inhibitor of gp130. Binds to gp130 and induces its phosphorylation at Ser782 in ovarian cancer cells. Suppresses constitutive phosphorylation of and nuclear translocation of Stat3.
纯度规格:A cell-permeable compound that competitively binds to Hu antigen R (HuR; Ki = 350 nM) and disrupts the interaction of HuR and adenine- and uridine-rich element (ARE) of target mRNAs.