产品说明
一般描述
A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of c-Raf (IC50 = 70 nM). Inhibits c-Raf with ten-fold greater potency compared to B-Raf. Has no significant effect on many other protein kinases tested (even at 50 µM) with the exception of SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM).
A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC50 = 70 nM). Inhibits c-Raf with ten-fold increased potency compared to B-Raf, but does not inhibit many other protein kinases (even at 50 µM) with the exception of SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM). The inhibition of c-Raf by ZM 336372 is competitive with respect to ATP.
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Primary Target
Protein kinase c-Raf
Reversible: yes
Cell permeable: yes
Product competes with ATP.
Target IC50: 70 nM against protein kinase c-Raf
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
其他说明
Hall-Jackson, C.A., et al. 1999. Chem. Biol.6, 559.
法律信息
Sold under license of PCT Application W098/22,103.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C23H23N3O3 |
| 分子量 | 389.45 |
| MDL编号 | MFCD02683971 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze protect from light |
| 颜色 | off-white |
| 溶解性 | DMSO: 200 mg/mL |
| 运输 | ambient |
| 储存温度 | −20℃ |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H317 - H413 |
| 预防措施声明 | P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313 |
| 危险分类 | Aquatic Chronic 4 - Skin Sens. 1B |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
