MMP-2/MMP-9 Inhibitor II-CAS 193807-60-2-Calbiochem

产品说明

一般描述

A potent inhibitor of MMP-2 (IC₅₀ = 17 nM) and MMP-9 (IC₅₀ = 30 nM). Also shown to potently induce and rapidly activate HIF. Reported to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.
A potent inhibitor of type IV collagenases, MMP-2 (IC₅₀ = 17 nM) and MMP-9 (IC₅₀ = 30 nM). Also shown to potently induce and rapidly activate HIF. Has been shown in vivo to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
MMP-2
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Target IC₅₀: 17 nM, 30 nM against MMP-2, and MMP-9, respectively

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Lauzier, M.C., et al. 2008. Mol. Pharmacol.In press.
Mifune, M., et al. 2005. J. Biol. Chem.280, 26592.
Zhang, H., et al. 2004. Circ. Res.95, 989.
Tamura, Y., et al. 1998. J. Med. Chem.41, 640.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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