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位置:首页 > 品牌 > Sigma-Aldrich > HIV-TAT48-57-β-Ala-Bcl-x L BH44-23, Ac-GRKKRRQRRR-βA-SNRELVVDFLSYKLSQKGYS-OH

Bcl-xL BH44-23, Human, Cell-Permeable-Calbiochem

HIV-TAT48-57-β-Ala-Bcl-x L BH44-23, Ac-GRKKRRQRRR-βA-SNRELVVDFLSYKLSQKGYS-OH

品牌
Sigma-Aldrich
货号
197217
规格纯度
A cell-permeable peptide that prevents apoptotic cell death by directly binding to the voltage-dependent anion channel (VDAC) and blocking its activity.
参考价格
4399.61 *本价格含增值税费
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数量
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产品名称:
Bcl-xL BH44-23, Human, Cell-Permeable-Calbiochem
HIV-TAT48-57-β-Ala-Bcl-x L BH44-23, Ac-GRKKRRQRRR-βA-SNRELVVDFLSYKLSQKGYS-OH
产品介绍:

产品说明

一般描述

A cell-permeable peptide that prevents apoptotic cell death by directly binding to the voltage-dependent anion channel (VDAC) and blocking its activity. Leads to the inhibition of cytochrome c release and loss of mitochondrial membrane potential (ΔΨm). Contains the conserved N-terminal homology domain (BH4) of Bcl-xL (amino acids 4 - 23) that has been shown to be essential for inhibiting VDAC activity in liposomes and in isolated mitochondria. The BH4 domain is linked to a carrier peptide, a 10-amino acid HIV-TAT48-57 sequence with a β-alanine residue as a spacer for maximum flexibility. Following its uptake, it is mainly localized to the mitochondria.
A highly cell-permeable peptide that prevents apoptotic cell death by directly binding to the voltage-dependent anion channel (VDAC) and blocking its activity. Ultimately results in the inhibition of cytochrome c release and loss of mitochondrial membrane potential (ΔΨm). Contains the conserved N-terminal homology domain (BH4) of Bcl-xL (amino acids 4-23) that has been shown to be essential for inhibiting VDAC activity in liposomes and isolated mitochondria. The BH4 domain is linked to the carrier peptide, the 10-amino acid HIV-TAT48-57 sequence with a β-alanine residue as a spacer for maximum flexibility. Following its uptake, it is mainly localized in the mitochondria.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
Voltage-dependent anion channel (VDAC)
Product does not compete with ATP.
Cell permeable: yes
Reversible: no

警告

Toxicity: Standard Handling (A)

序列

Ac-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-βAla-Ser-Asn-Arg-Glu-Leu-Val-Val-Asp-Phe-Leu-Ser-Tyr-Lys-Ser-Gln-Lys-Gly-Tyr-Ser-OH

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Chen m., et al. 2002. J. Biol. Chem. 277, 29181.
Futaki, S., et al. 2001. J. Biol. Chem.276, 5836.
Shimizu, S., et al. 2000. Proc. Natl. Acad. Sci. USA97, 3100.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C165H279N59O46
分子量3825.35

产品性质

质量水平100
测定≥95% (HPLC)
形式lyophilized
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
溶解性20% acetic acid: 5 mg/mL
DMSO: 5 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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