FPT Inhibitor II-Calbiochem

产品说明

一般描述

A highly selective and potent inhibitor of Ras farnesyltransferase (IC₅₀ = 75 nM). Inhibits geranylgeranyltransferase I (IC₅₀ = 24 µM) and II (IC₅₀ = 24 µM) at much higher concentrations. Also inhibits Ras farnesylation in whole cells by ~90% at 10-100 µg/ml (25-250 µM). Resistant to cleavage by phosphorylation.
A cell permeable potent and selective inhibitor of farnesyltransferase (FTase; IC₅₀ = 75 nM). Also inhibits Ras farnesylation in whole cells by ~90% at 25-250 µM. Resistant to cleavage by phosphorylation.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

包装

1 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Target IC₅₀: 75 nM against Ftase
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

其他说明

Manne, V., et al. 1995. Drug Development Res.34, 121.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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