产品说明
一般描述
A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM) and protein kinase C (Ki = 42 µM) at much higher concentrations.
A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM)and protein kinase C (Ki = 42 µM) at much higher concentrations.
包装
1 mg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Product competes with ATP.
Target Ki: 300 nM against myosin light chain kinase
Primary Target
Myosin light chain kinase (Mlck)
Reversible: yes
警告
Toxicity: Standard Handling (A)
制备说明
Further dilute with aqueous buffer just prior to use.
重悬
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
其他说明
Krarup, T., et al. 1998. Am. J. Physiol. 275, C239.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C15H17IN2O2S · xHCl |
| 分子量 | 416.28 (free base basis) |
| MDL编号 | MFCD00065524 |
产品性质
| 质量水平 | 100 |
| 测定 | >98% (TLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 颜色 | white |
| 溶解性 | 50% ethanol: 4.5 mg/mL DMSO: 4.5 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| InChI | 1S/C15H17IN2O2S/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18/h1-2,4-7,17H,3,8-11H2 |
| InChI key | GEHJIACZUFWBTK-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
