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FTase Inhibitor I-Calbiochem

品牌
Sigma-Aldrich
货号
344510
规格纯度
The FTase Inhibitor I controls the biological activity of FTase. This small molecule/inhibitor is primarily used for Cancer applications.
参考价格
2741.8 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
FTase Inhibitor I-Calbiochem
N-[2(S)-[2(R)-Amino-3-mercaptopropylamino]-3-methylbutyl]-Phe-Met-OH, B581
产品介绍:

产品说明

一般描述

A potent, cell-permeable inhibitor of farnesyltransferase (FTase) that is about 37-fold more active against FTase (IC50 = 21 nM in vitro) than against geranylgeranyltransferase (GGTase; IC50 = 790 nM). Very resistant to proteolysis.
A potent, cell-permeable, selective, peptidomimetic inhibitor of farnesyltransferase (FTase) that is approximately 37-fold more active against FTase (IC50 = 21 nM in vitro) than against geranylgeranyltransferase (GGTase; IC50 = 790 nM). Very resistant to proteolysis.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Target IC50: 21 nM against FTase in vitro
Product does not compete with ATP.
Primary Target
FTase
Cell permeable: yes
Reversible: no

警告

Toxicity: Standard Handling (A)

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Yamaguchi, M., et al. 2004. Stroke35, 1750.
Cox, A.D., et al. 1994. J. Biol. Chem.269, 19203.
Garcia, A.M., et al. 1993. J. Biol. Chem. 268, 18415.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C22H38N4O3S2
分子量470.69

产品性质

质量水平100
测定≥90% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
颜色 white
溶解性water: 1 mg/mL
DMSO: 5 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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