产品说明
一般描述
An endogenous protease inhibitor that acts specifically on Calpain I (Cat. No. 208712), a Ca2+-dependent cysteine protease. Widely distributed in mammalian and avian cells. Has better inhibitory action than Calpain Inhibitor I (Cat. No. 208719) and Calpain Inhibitor II (Cat. No. 208721). Calpastatin corresponds to domain I of human calpastatin. The inhibitory sequence of human domain I consists of at least 18 amino acid residues.
Domain I of human calpastatin. Endogenous protease inhibitor that acts specifically on Calpain-1 (Cat. No. 208712). Exhibits greater inhibitory potency than calpain inhibitors I and II.
包装
1 mg in Glass bottle
生化/生理作用
Product does not compete with ATP.
Primary Target
calpain-1
50 nM completely inhibits the activity of 7.5 µg/ml calpain I
Reversible: no
Cell permeable: no
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
分析说明
homogeneous by SDS-PAGE
其他说明
Salamino, F., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1326.
Uemori, T., et al. 1990. Biochem. Biophys. Res. Commun. 166, 1485.
Asada, K., et al. 1989. J. Enzyme Inhib.3, 49.
法律信息
Not available for sale in Japan.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
质量水平 | 100 |
形式 | lyophilized solid |
manufacturer/tradename | Calbiochem® |
储存条件 | OK to freeze |
颜色 | white |
溶解性 | aqueous buffer: 1 mg/mL water: 1 mg/mL |
运输 | wet ice |
储存温度 | −20℃ |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich