氨基蝶呤成品溶液

产品名称：

54-62-6
Aminopterin Ready Made Solution
4-Aminofolic Acid
(S)-2-{4-[(2,4-Diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid
4-Amino-PGA
4-Aminopteroyl-L-glutamic Acid
氨基蝶呤成品溶液
4-氨基-PGA
4-氨基叶酸

产品介绍：

产品说明

生化/生理作用

Aminopterin is a synthetic derivative of pterin. It is used as a folic acid antagonist. It competitively inhibits dihydrofolate reductase (DHFR) and blocks tetrahydrofolate synthesis. This inhibition blocks DNA, RNA and protein synthesis.
Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Aminopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase.
Aminopterin was first administered for cancer therapy, as a drug targeting metabolism, specifically in pediatric leukemia. Later on it was demonstrated to be more potent yet more toxic than methotrexate.

基本信息

经验(实验)分子式	C₁₉H₂₀N₈O₅
分子量	440.41
MDL编号	MFCD00036692

产品性质

测定	≥85%
质量水平	200
形式	liquid
储存条件	protect from light
浓度	50 mg/mL in DMSO
溶解性	DMSO: 50 mg/mL
运输	dry ice
储存温度	−20℃
SMILES string	OC(CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=NC3=C(N)N=C(N)N=C3N=C2)C=C1)=O)=O
InChI	1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)
InChI key	TVZGACDUOSZQKY-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H360
预防措施声明	P201 - P280 - P301 + P330 + P331 + P310 - P308 + P313
危险分类	Acute Tox. 3 Oral - Repr. 1B
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	188.6 °F
闪点(C)	87 ℃