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Anti-Interleukin-10 antibody produced in goat

抗-白介素-10 山羊抗

品牌
Sigma-Aldrich
货号
I5145
规格纯度
IgG fraction of antiserum, lyophilized powder
参考价格
4731.57 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
Anti-Interleukin-10 antibody produced in goat
Anti-IL-10
抗-白介素-10 山羊抗
产品介绍:

产品说明

一般描述

Interleukin-10 (IL-10) is a pleotropic cytokine with anti-inflammatory and immunosuppressive functions. It is the key cytokine that regulates the host inflammatory responses to bacterial, fungal and viral pathogens. The production of IL-10 is mediated by signalling of IL-6, IL-12 and TGF-β. IL-10 is secreted by a variety of cells including T cells, B cells, dendritic cells, eosinophils, natural killer cells and mast cells. The effects of IL-10 are mediated by binding to the IL-10R, consisting of α and β subunits. The signalling through IL-10R activates Jak1, Tyk2 protein kinases and JAK/STAT3 pathways. IL-10 is involved in suppression of innate immunity to kill pathogens and inhibits the release of reactive oxygen and nitrogen species from activated macrophages. Regulation of IL-10 production is important in infections, inflammatory responses in autoimmune encephalomyelitis, endotoxic shock and chronic enterocolitis
Anti-interleukin-10 antibody is specific for mouse IL-10. The antibody shows less than 5% cross reactivity to recombinant human IL-10.

特异性

The antibody neutralizes the biological activity of recombinant mouse IL-10.

免疫原

recombinant mouse IL-10 expressed in E. coli.

应用

Anti-interleukin-10 antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. The antibody is suitable for neutralization reactions (ND50 is 2-4 μg/ml).

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

制备说明

Purified using protein G.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

EC 号202-739-6
MDL编号MFCD00241897
NACRESNA.41

产品性质

质量水平100
生物来源goat
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式lyophilized powder
species reactivitymouse
technique(s)neutralization: suitable
western blot: suitable
UniProt登记号P18893
储存温度−20℃
Gene Informationmouse ... Il10(16153)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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