Anti-phospho-DARPP32 (pThr³⁴) antibody produced in rabbit

产品说明

一般描述

DARPP32 is a phosphoprotein with a molecular mass of 32kDa. It is regulated by dopamine (DA) and cAMP and is associated with dopaminoceptive neurons bearing D-1 receptors in the basal ganglia. DARPP32 is a target for the actions of dopamine.

免疫原

synthetic phosphopeptide corresponding to amino acids residues surrounding the DARPP32 phosphorylated on threonine 34

生化/生理作用

Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32. When phosphorylated on threonine 34, DARPP32 acts as a potent protein phosphatase- inhibitor. This phosphorylation plays an important role in the regulation of dopaminergic neurotransmission. The activity of this protein has an important role in the actions of alcohol, caffeine and Prozac^®.

目标描述

DARPP32 phosphorylated on Thr⁷⁵ acts as an inhibitor of PKA.

外形

Solution at 100 μL in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol.

法律信息

Prozac is a registered trademark of Eli Lilly and Co.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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