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Anti-phospho-p53 (pSer392) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
P8982
规格纯度
affinity isolated antibody, buffered aqueous glycerol solution
参考价格
4731.57 *本价格含增值税费
促销
服务
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数量
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产品名称:
Anti-phospho-p53 (pSer392) antibody produced in rabbit
产品介绍:

产品说明

一般描述

p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.

特异性

Does not react with non-phosphorylated p53.

免疫原

synthetic peptide corresponding to residues around Ser392 of human p53 conjugated to KLH.

生化/生理作用

Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.

外形

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol

制备说明

Purified using protein A and peptide affinity chromatography.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD02097164
NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous glycerol solution
分子量antigen 53 kDa
species reactivitymouse, human
technique(s)microarray: suitable
western blot (chemiluminescent): 1:1,000 using p53 fusion proteins with CKII phosphorylation or an extract of hydroxyurea-treated MvILu cells
UniProt登记号P04637
运输wet ice
储存温度−20℃
Gene Informationhuman ... TP53(7157)
mouse ... Trp53(22059)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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