产品说明
一般描述
Aphidicolin is a tetracyclic diterpene with antiviral and antimitotic properties used for cell cycle synchronization in various cell lines.
应用
Aphidicolin, from Nigrospora sphaerica, was used for cell cycle synchronization of tobacco BY-2 cells. It is used to block the entry of cells into S-phase.
生化/生理作用
Aphidicolin specifically inhibits DNA polymerase α that is responsible for DNA replication. It also inhibits α-like DNA polymerases of plants and yeasts but does not inhibit synthesis of RNA and proteins. Aphidicolin competes for the dCTP-specific binding site on DNA polymerase α specifically. Aphidicolin has antiviral and antimitotic properties. It blocks the cell cycle at S phase. It has been shown to induce apoptosis in HeLa cells.
包装
1 ml
外形
Aphidicolin Ready Made Solution supplied as a 1 mg/ml solution in DMSO.
其他说明
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids
基本信息
| 经验(实验)分子式 | C20H34O4 |
| 分子量 | 338.48 |
| EC 号 | 200-664-3 |
| MDL编号 | MFCD00083214 |
| NACRES | NA.85 |
产品性质
| 生物来源 | Nigrospora sphaerica |
| 质量水平 | 200 |
| 蒸汽压 | 0.55 hPa ( 20 ℃) |
| 形式 | liquid |
| 颜色 | clear colorless |
| 溶解性 | H2O: miscible (completely) |
| 作用机制 | DNA synthesis | interferes enzyme | inhibits |
| 抗生素抗菌谱 | neoplastics viruses |
| 储存温度 | −20℃ |
| InChI | 1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1 |
| InChI key | NOFOAYPPHIUXJR-APNQCZIXSA-N |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | 188.6 °F - closed cup |
| 闪点(C) | 87 ℃ - closed cup |
Sigma-Aldrich
m.cnreagent.com
