MMP-13 Inhibitor-CAS 544678-85-5-Calbiochem

产品说明

一般描述

A potent inhibitor of MMP-13 activity (IC₅₀ = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor.
A pyrimidine dicarboxamide compound that potently inhibits MMP-13 activity (IC₅₀ = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
MMP-13 activity
Product does not compete with ATP.
Target IC₅₀: 8 nM against MMP-13
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

制备说明

Further dilute in buffer immediately prior to use.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Engel, C.K., et al. 2005. Chem. Biol.12, 181.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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