产品说明
生化/生理作用
Terrein is a bioactive fungal metabolite that has plant growth inhibition and antibacterial activities. Terrein reduces melanin levels in a dose-dependent manner as well as tyrosinase protein production. In mammals, there are three melanocyte-specific enzymes: tyrosinase, tyrosinase-related protein-1 (TRP-1), and TRP-2 that are involved in tyrosine conversion into melanin (melanogenesis). Terrein inhibits melanin synthesis by reducing tyrosinase production via extracellular signal-regulated protein kinase (ERK) activation. ERK activation is followed by microphthalmia-associated transcription factor (MITF) down regulation, which is required for tyrosinase expression.
制备说明
Terrein is soluble in water at 1-1.10 mg/ml and yields a clear, colorless solution. It is also soluble in DMSO. Hence, the product may be reconstituted in water or DMSO.
基本信息
| 经验(实验)分子式 | C8H10O3 |
| 分子量 | 154.16 |
| NACRES | NA.77 |
产品性质
| 生物来源 | Aspergillus terreus |
| 质量水平 | 200 |
| 测定 | ≥98% (HPLC) |
| 储存条件 | protect from light |
| 溶解性 | H2O: soluble 1-1.10 mg/mL, clear, colorless DMSO: soluble |
| 储存温度 | −20℃ |
| InChI | 1S/C8H10O3/c1-2-3-5-4-6(9)8(11)7(5)10/h2-4,7-8,10-11H,1H3/b3-2+ |
| InChI key | MHOOPNKRBMHHEC-NSCUHMNNSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
