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Purvalanol A-CAS 212844-53-6-Calbiochem

品牌
Sigma-Aldrich
CAS
212844-53-6
货号
540500
规格纯度
A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases.
参考价格
1516.74 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
212844-53-6
Purvalanol A-CAS 212844-53-6-Calbiochem
2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine
产品介绍:

产品说明

一般描述

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC50 = 4 nM for Cdc2-cyclin B; IC50 = 70 nM for Cdk2-cyclin A; IC50 = 35 nM for Cdk2-cyclin E; and IC50 = 75 nM for Cdk5-p35).
A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC50 = 4 nM for Cdc2/cyclin B; IC50 = 70 nM for Cdk2/cyclin A; IC50 = 35 nM for Cdk2/cyclin E; and IC50 = 75 nM for Cdk5/p35).

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Primary Target
Cdc2/cyclin B
Reversible: yes
Cell permeable: yes
Target IC50: 4 nM for Cdc2/cyclin B; 70 nM for Cdk2/cyclin A; 35 nM for Cdk2/cyclin E; 75 nM for Cdk5/p35

警告

Toxicity: Standard Handling (A)

重悬

Following initial thaw, aliquot and freeze (-20°C).

其他说明

Gray, N.S., et al. 1998. Science 281, 533.

法律信息

Sold under license of U.S. Patents 6,617,331 and 6,803,371.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C19H25ClN6O
分子量388.89
MDL编号MFCD02179211

产品性质

质量水平100
测定≥97% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
颜色 off-white
溶解性DMSO: 100 mg/mL
运输ambient
储存温度−20℃
InChI1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1
InChI keyPMXCMJLOPOFPBT-HNNXBMFYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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