Receptor activator of NF-κB

产品名称：

RANK/Fc Chimera from mouse
Osteoclast differentiation receptor, ODFR
Receptor activator of NF-κB

产品介绍：

产品说明

应用

RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. The biological functions mediated by RANK include activation of NF-ΚB and c-jun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis and lymph node organogenesis.

生化/生理作用

TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for RANK. The biological functions mediated through RANK include activation of NF-κB and c-jun N-terminal kinases, enhancement of T cell growth and dentritic cell function, induction of osteoclastogenesis, and lymph node genesis. Soluble RANK is able to block TRANCE-induced biological activity.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

分析说明

The biological activity is measured by its ability to inhibit TRANCE-induced osteoclast differentiation in mouse splenocytes.

基本信息

MDL编号	MFCD03703131
NACRES	NA.32

产品性质

质量水平	200
生物来源	mouse
重组	expressed in NSO cells
测定	≥95% (SDS-PAGE)
形式	lyophilized powder
效能	10.12 μg/mL EC₅₀
分子量	60 kDa
包装	pkg of 1 mg
储存条件	avoid repeated freeze/thaw cycles
technique(s)	cell culture \| mammalian: suitable
杂质	endotoxin, tested
UniProt登记号	O35305
储存温度	−20℃
Gene Information	mouse ... Tnfrsf11a(21934)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable