5-[<I>N</I>-（3，4-二甲氧基苯基乙基）甲胺基]-2-（3，4-二甲氧基苯基）-2-异丙基戊腈α；盐酸盐

产品名称：

152-11-4
Verapamil Hydrochloride
5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride
(±)-Verapamil hydrochloride
维拉帕米
（±）-维拉帕米盐酸盐
5-[N-（3，4-二甲氧基苯基乙基）甲胺基]-2-（3，4-二甲氧基苯基）-2-异丙基戊腈α；盐酸盐

产品介绍：

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

α₁-肾上腺素受体拮抗剂；L型钙通道阻滞剂。阻断平滑肌和心肌中的 L 型 Ca²⁺ 通道，体外诱导人原发性和转移性结肠癌细胞的凋亡。对 PGP 起作用的抗药性逆转剂，如减少肾小管清除地高辛。增加 Pgp 的基础 ATP 酶活性。Cyp3A4 和 CYP2C6 的底物。

包装

Unit quantity: 50 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

线性分子式	(CH₃O)₂C₆H₃CH₂CH₂N(CH₃)(CH₂)₃C[C₆H₃(OCH₃)₂][CH(CH₃)₂]CN · HCl
分子量	491.06
Beilstein	3647093
MDL编号	MFCD00055208
PubChem化学物质编号	329828921
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
agency	EP Reference Standard
manufacturer/tradename	EDQM
mp	142 ℃ (dec.) (lit.)
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
InChI	1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
InChI key	DOQPXTMNIUCOSY-UHFFFAOYSA-N
Gene Information	human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H411
预防措施声明	P264 - P270 - P273 - P301 + P310 - P391 - P405
危险分类	Acute Tox. 3 Oral - Aquatic Chronic 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

Verapamil Hydrochloride

（±）-维拉帕米 盐酸盐

（±）-维拉帕米盐酸盐